Going to work during the COVID-19 pandemic has put frontline workers under enormous and unprecedented pressure, endangering their physical and psychological well-being and social well-being. Employees subject to increased or prolonged stress become more susceptible to frequent absenteeism or lack of productivity during work, accidents and errors. In the course of the COVID- 19 pandemic, the foregoing may cause quality and safety of care, breach of protocols and guidelines, increased risk of infection, and weakened health system and emergency response teams to combat the pandemic. While frontline workers are responsible for caring for themselves and expressing their needs and concerns, organizations, managers and health administrators have to make many efforts to prevent and reduce stress and take care of the mental health of frontline workers.